Carfilzomib Intermediation

Carfilzomib Intermediation

Cas # 868540- 17- 4} ap
# {{247068- 85- 5}, n -1 Ruam
# {{868540- 16- 3. N -1 theem
# {247068- 82- 2
# {868540- 15- 2

Dawb rau off-dawb crystalline hmoov

Purity ntau dua lossis sib npaug rau 98. 0% (los ntawm HPLC)

Carfilzomib yog lub zog, tsis muaj protasome protasome inhibitor muaj rau kev kho mob ntawm ntau Myeloma. Nws xaiv rau ChymottryPSin zoo li kev ua ntawm 20s protasas, uas yog qhov ua rau muaj cov protein thiab thaum kawg ua rau muaj kev sib faib ntshav tsis huv.

Thim rov qab los yog refractory ntau myeloma:
Carfilzomib yog kev pom zoo rau cov neeg mob uas tau txais ib lossis ntau dua kev pabcuam ua ntej.
Nws yog feem ntau tswj hwm:
Raws li monotherapy nrog dexamethasone.
Ua ke nrog Lenidomomide thiab Dexamethasone (Krd regimen).
Ua ke nrog Daratumumab thiab dexamethasone (KDD Degtimen).
Kev sim khomob (piv txwv li kev sim siab, kev kawm txog kev muaj sia nyob tseem ceeb (OS), thiab cov lus teb tag nrho piv rau cov qauv kev kho mob.

Thawj-kab kev tsav tsheb (nyob rau hauv kev tshawb nrhiav kev tshawb nrhiav):
Carfilzomib-raws li cov kev daws teeb meem yog ib feem ntawm kev tsim kho thawj zaug rau kev kuaj mob myeloma, tshwj xeeb tshaj yog ua ke nrog immunomodulators thiab monoclonal tshuaj tiv thaiv.
Cov lus cog tseg tawm tswv yim qhia kom tau qhov tob thiab tus kab mob tsawg dua (MRD) negativity tus nqi.

High-pheej hmoo cytogenetic ntau myeloma:
Cov neeg mob uas muaj kev pheej hmoo siab cytogenetic nta (piv txwv li, t (4; 14), t (14), del (17p)) feem ntau muaj qhov txiaj ntsim tsis zoo. Carfilzomib-raws li kev kho mob tau pom tias txo qhov tsis zoo ntawm cov kev txawv txav no rau qee yam.

Cov neeg mob tsis muaj cov neeg ua haujlwm ua ntej-production protasove inhibitors:
Piv nrog Bortezomib, Carfilzomib muaj qhov qis dua ntawm peripheral neuropathy, ua rau nws xaiv qhov tsis txaus ntseeg lossis muaj kev pheej hmoo ntawm cov kev mob tshwm sim lossis muaj kev pheej hmoo.

Lwm cov kev tshawb nrhiav tau siv tau:
Kev tshawb fawb txuas ntxiv yog tshawb txog CarFilzomib hauv:
Kev sib xyaw nrog anti-CD38 tshuaj tiv thaiv (piv txwv li, iTatuximab)
Smoldering ntau yam myeloma (SMM) kom ncua sij hawm kev ncua
Rov huam / refractory lub teeb saw (al) amylaoids duab

Conforms rau USP thiab EP.

Khw ntawm 2 Qib rau 8 degree (36 Degree F rau 46 Degree F).
Tiv thaiv los ntawm lub teeb, noo noo, thiab ntau dhau.
Khaws rau hauv thawj, kaw lub thawv kaw.

Cim npe nrov: Carfilzomib Intermediate, Tuam Tshoj Carfilzomib Infolmediat Cov Chaw Tsim Tshuaj, Cov Chaw Muag Khoom