Eribulin intermediate

Eribulin intermediate

# {157322- 83- 3
# {157322- 47- 9
# {871348- 24- 2

Dawb rau off-dawb crystalline hmoov lossis amorphous khoom, nyob ntawm theem ntawm synthesis.

Kws Tshuaj Nruab Nrab

Purity: ntau dua los yog sib npaug rau 98. {0% (txiav txim los ntawm HPLC lossis NMR)

Epibulin yog cov neeg them se hluav taws xob uas tsis yog se hluav taws xob hluav taws xob siv incibitor siv nyob rau hauv oncology rau kev kho cov qog ua tau zoo tshaj plaws. Nws muab nws cov nyhuv antitumor los ntawm kev khi rau cov zuj zus ntawm cov microlotubules, ua rau cov tsis muaj suab paj nruag uas tsis pom kev thiab ua kom huv. Ib qho ntxiv, nws ua rau kev hloov pauv epithelial-rau-mesenchymal hloov (EMT), txo cov qog ntawm lub cev kom zoo thiab kho cov qog ntshav vasculature.

MetaStic Mis Cancer (MBC):
ERIBULIN tau pom zoo rau kev kho mob ntawm cov neeg mob cancer mis los ntawm cov neeg mob uas tau txais ob qho kev kuaj mob ua ntej, suav nrog tus kws kho mob thiab tus neeg them se.
Cov chaw kuaj mob muaj xws li:
Qhov tseem ceeb txhim kho nyob rau hauv tag nrho ciaj sia (OS) piv rau kws kho mob xaiv kho tshuaj kho mob.
Ua kom pom kev ua tau zoo hauv peb lub mis nyuj tsis zoo (TNBC), ib tug subtype txuam nrog kev siv hluav taws xob tsis zoo thiab txo cov kev kho mob tsawg.
Qhia kom rov qab EMT, ua rau cov qog nqaij tawv rhiab rau kev siv tshuaj kho mob.
Txo cov qog ntxeem tau thiab tsiv teb tsaws chaw, yog li kev txwv metastatic sib kis.

Unresects lossis metastatic liposarcoma:
Epibulin tseem qhia txog kev kho mob ntawm kev ua haujlwm siab dhau los, tshwj xeeb yog tom qab tsis ua haujlwm ntawm kev ua haujlwm ntsuas tshuaj.
Qhov tseem ceeb kho nta:
Tsuas yog ib tus neeg sawv cev tsuas qhia rau lub sijhawm puv ntoob hauv Liposarcoma hauv ib theem III mus sib hais.
Ua tau zoo nyob rau hauv Dedifferentiated, Pleomorphic, thiab myxoid / Round Cell Subtypes.
Muaj cov txiaj ntsig kev kho mob txawm tias nyob rau hauv cov qog refractory thiab cov neeg mob uas tsis zoo.
Mob qog kom nruj thiab txhim kho kom zoo ntawm lub neej nyob rau hauv mos mos Sarcoma cov neeg mob.

Kev tshawb fawb thiab tawm-daim ntawv lo rau npe siv:
Eribulin yog nyob rau hauv kev tshawb nrhiav hauv:
Tsis yog-me me cell mob cancer (NSCLC)
Platinum-resistant Ovarian Cancer
Mos nqaij sawbaras uas tsis yog liposarcoma
Endometrial thiab plab hnyuv cancers
Kev kho mob nrog cov tshuaj tiv thaiv kab tiv thaiv kev tiv thaiv kab mob thiab cov tshuaj tiv thaiv Antiangiogenic

Conforms rau USP thiab EP.

Khw Muag Khoom ntawm 2 Qib rau 8 degree, tiv thaiv los ntawm lub teeb thiab noo noo.
Khaws cia hauv cov thawv kaw ntom ntom ntom ntom ntom ntom.
Ruaj khov rau kev thauj mus los nyob hauv cov huab cua ambient rau lub sijhawm tsawg.

Cim npe nrov: Epibulin Intermediat, Tuam Tshoj eribulin intermediat manufacturers, lwm tus neeg